THE USE OF A PROLINE RING AS A CONFORMATIONAL RESTRAINT IN CCK-B RECEPTOR DIPEPTOIDS

被引：13

作者：

FINCHAM, CI ^{[1
]}

HORWELL, DC ^{[1
]}

RATCLIFFE, GS ^{[1
]}

REES, DC ^{[1
]}

机构：

[1] PARKE DAVIS NEUROSCI RES CTR,ADDENBROOKES HOSP,HILLS RD,CAMBRIDGE CB2 2QB,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(00)80156-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Examination of molecular dynamics simulations and an X-ray crystal structure of a selective CCK-B receptor dipeptoid Trp derivative led to the synthesis of a conformationally restrained Pro derivative. The CCK receptor binding of this target compound (7) is described.

引用

页码：403 / 406

页数：4

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