EVIDENCE FOR MNEMOTROPIC ACTION OF CHOLECYSTOKININ FRAGMENTS BOC-CCK-4 AND CCK-8S

被引:38
作者
GERHARDT, P
VOITS, M
FINK, H
HUSTON, JP
机构
[1] UNIV DUSSELDORF, INST PHYSIOL PSYCHOL 1, D-40225 DUSSELDORF, GERMANY
[2] HUMBOLDT UNIV BERLIN, INST PHARMACOL & TOXICOL CHARITE, D-10117 BERLIN, GERMANY
关键词
CHOLECYSTOKININ (CCK); CCK-8S; BOC-CCK-4; HABITUATION; HOLE-BOARD; OPEN FIELD; RAT; EXPLORATORY BEHAVIOR; MEMORY;
D O I
10.1016/0196-9781(94)90097-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Memory-modulating and reinforcing effects of the cholecystokinin (CCK) fragments, CCK-8S and Boc-CCK-4, after systemic application in rats were investigated. Habituation to the novelty of environmental stimuli was used to test for mnemonic effects using two different tasks (rearing behavior in an open field; head-dips in a hole-board). Immediate posttrial administration of CCK-8S and Boc-CCK-4 resulted in a reduction of rearing and head-dip behavior during testing, indicative of enhanced habituation and, thus, facilitation of memory. In contrast, administration of CCK-8S and Boc-CCK-4 with a delay of 2.5 or 5 h after training or pretrial injection of CCK-8S did not enhance habituation. No evidence for reinforcing or aversive properties of CCK-8S and Boc-CCK-4 was observed in a conditioned place preference task. In summary, the results indicate memory-enhancing effects of peripherally, posttrial-administered CCK-8S and Boc-CCK-4.
引用
收藏
页码:689 / 697
页数:9
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