BASE OF SKULL AND CERVICAL-SPINE CHORDOMAS IN CHILDREN TREATED BY HIGH-DOSE IRRADIATION

被引:106
作者
BENK, V
LIEBSCH, NJ
MUNZENRIDER, JE
EFIRD, J
MCMANUS, P
SUIT, H
机构
[1] MASSACHUSETTS GEN HOSP,DEPT RADIAT ONCOL,BOSTON,MA 02114
[2] HARVARD UNIV,SCH MED,BOSTON,MA
[3] HARVARD UNIV,CYCLOTRON LAB,CAMBRIDGE,ENGLAND
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1995年 / 31卷 / 03期
关键词
CHORDOMA; SKULL NEOPLASM; TREATMENT; RADIOTHERAPY; PROTON THERAPY;
D O I
10.1016/0360-3016(94)00395-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: To evaluate the outcome of children with base of skull or cervical spine chordomas treated by high dose irradiation. Methods and Materials: Eighteen children, 4 to 18 years of age, with base of skull or cervical spine chordomas, received fractionated high-dose postoperative radiation using mixed photon and 160 MeV proton beams, The median tumor dose was 69 Cobalt Gray-equivalent (CGE) with a 1.8 CGE daily fraction. Results: The median follow-up was 72 months, The 5-year actuarial survival was 68% and the 5-year disease-free survival (DFS) was 63%. The only significant prognostic factor was the location: patients with cervical spine chordomas had a worse survival than those with base of skull lesions (p = 0.008). The incidence of treatment-related morbidity was acceptable: two patients developed a growth hormone deficit corrected by hormone replacement, one temporal lobe necrosis, and one fibrosis of the temporalis muscle, improved by surgery. Conclusion: Chordomas in children behave similarly to those in adults: children can receive the same high-dose irradiation as adults with acceptable morbidity.
引用
收藏
页码:577 / 581
页数:5
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