AGE AND THE EFFECTS OF 2-D,L-AMINO-5-PHOSPHONOVALERATE IN AN AREA OF THE CHICK FOREBRAIN WHICH IS ESSENTIAL FOR EARLY LEARNING

被引：10

作者：

BRADLEY, PM

BURNS, BD

KING, TM

WEBB, AC

机构：

[1] UNIV NEWCASTLE UPON TYNE,SCH MED,SCH NEUROSCI,DIV NEUROBIOL,NEWCASTLE TYNE NE2 4HH,TYNE & WEAR,ENGLAND

[2] UNIV LONDON,ST MARYS HOSP,IMPERIAL COLL,SCH MED,DEPT PHYSIOL & BIOPHYS,LONDON W2 1P,ENGLAND

来源：

BRAIN RESEARCH | 1995年 / 699卷 / 01期

关键词：

CHICK FOREBRAIN; LEARNING; SYNAPTIC PLASTICITY; NMDA-RECEPTOR;

D O I：

10.1016/0006-8993(95)00897-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The intermediate, medial part of the hyperstriatum ventrale (IMHV) is a region of the avian forebrain which is known to be essential for early learning in the domestic chick. The IMHV in an in vitro slice preparation displays two forms of synaptic plasticity. The incidence of both varies with age and is maximal between 3 and 5 days post-hatch. Since NMDA receptors are critical for at least one of these plasticities, we have investigated the relationship between age and the contribution of NMDA receptors to the field response evoked by local, low-frequency stimulation and have found that the magnitude of the NMDA-dependent component of the response varies with age, peaking between 3 and 5 days post-hatch. Spontaneous neural activity, recorded intracellularly, can be completely and reversibly silenced by NMDA receptor blockade and the incidence of spontaneous activity also varies with age, peaking between 3 and 5 days. These results suggest that the IMHV contains NMDA receptors which can be activated near resting membrane potential. Either the efficiency or the numbers of these receptors is maximal at a specific point in development and their peak activity coincides with a peak in synaptic plasticity. These characteristics are similar to those reported for young mammals.

引用

页码：103 / 108

页数：6

共 21 条

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