IDENTIFICATION OF A MAJOR T-CELL EPITOPE WITHIN VP3 AMINO-ACID-RESIDUES 24 TO 37 OF THEILERS-VIRUS IN DEMYELINATION-SUSCEPTIBLE SJL/J MICE

被引:41
作者
YAUCH, RL
KEREKES, K
SAUJANI, K
KIM, BS
机构
[1] NORTHWESTERN UNIV,SCH MED,DEPT MICROBIOL IMMUNOL,CHICAGO,IL 60611
[2] NORTHWESTERN UNIV,SCH MED,DEPT PATHOL,CHICAGO,IL 60611
关键词
D O I
10.1128/JVI.69.11.7315-7318.1995
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Intracerebral inoculation of susceptible strains of mice with Theiler's murine encephalomyelitis virus (TMEV) results in a chronic, immunologically mediated demyelinating disease that shares many features with human multiple sclerosis. CD4(+) T lymphocytes play a critical role in the pathogenesis of virus-induced demyelinating disease. We have identified a region within amino acid residues 24 to 37 of the VP3 capsid protein of TMEV (VP3(24-37)) that is recognized by T lymphocytes from the demyelination-susceptible SJL/J strain of mice. The T-cell response to VP3(24-37) represents a predominant Th-cell response against the virus from either TMEV-immunized or TMEV-infected SJL/J mice, and viral epitopes VP1(233-250), VP2(74-86), and VP3(24-37) account for most of the Th-cell response to TMEV.
引用
收藏
页码:7315 / 7318
页数:4
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