A RAPID ENTRY INTO THE DYNEMICIN CORE STRUCTURE - REMARKABLE SOLVENT EFFECT ON AN ETA-2-HEXACARBONYLDICOBALT PROPARGYLIC CATION CYCLIZATION

被引：60

作者：

MAGNUS, P

FORTT, SM

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 07期

关键词：

D O I：

10.1039/c39910000544

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

3-(tert-Butyldimethylsilyloxy)quinoline 8 on treatment with the diynene 9 gave the diynene 10 (64%), and deprotection of 10 gave 11 (88%) which was converted into the eta-2-Co2(CO)6 adduct 12; treatment of 12 with (CF3SO2)2O in CH2Cl2-MeNO2 at -10-degrees-C gave the cyclized product 13 (43%), and decomplexation of 13 using I2-THF produced the stable azabicyclo[7.3.1]tridecadiynene core structure 7 of the antitumour antibiotic dynemicin 1.

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页码：544 / 546

页数：3

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