FAT AND GASTRIC-ACID SECRETION

被引：7

作者：

PETERSEN, F

OLSEN, O

JEPSEN, LV

CHRISTIANSEN, J

机构：

[1] GLOSTRUP CTY HOSP,DEPT SURG D,DK-2600 GLOSTRUP,DENMARK

[2] UNIV COPENHAGEN,RIGSHOSP,DEPT SURG C,DK-2100 COPENHAGEN,DENMARK

来源：

DIGESTION | 1992年 / 52卷 / 01期

关键词：

GASTRIC ACID; PENTAGASTRIN; OLEIC ACID; OLEYL ALCOHOL; SECRETIN;

D O I：

10.1159/000200937

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

To evaluate the importance of the terminal carboxyl group of the oleic acid molecule in the inhibition of gastric acid secretion. 6 normal persons were stimulated twice with duodenal perfusates containing either 20 mM oleic acid or 20 mM oleyl alcohol. Oleic acid significantly inhibited the gastric acid secretion stimulated by pentagastrin (100 ng/kg/h) and in-creased the levels of secretin in plasma. The effect of oleyl alcohol was insignificant. It is concluded that the carboxyl group of the fat molecule has an important role in the inhibition of gastric acid secretion, and the effect could in part be attributable to the release of secretin into plasma.

引用

页码：43 / 46

页数：4

共 13 条

[1]

CHRISTIANSEN J, 1976, SCAND J GASTROENTERO, V11, P673

[2] MEAL-STIMULATED SECRETIN RELEASE IN MAN - EFFECT OF ACID AND BILE [J].