SYNTHESIS, ANTIPARASITIC AND ANTIFUNGAL ACTIVITY OF THIOUREINES WITH AMINO-ACID CHAIN

被引：6

作者：

CAUJOLLE, R

PAYARD, M

LOISEAU, PR

AMAROUCH, H

LINAS, MD

SEGUELA, JP

BORIES, C

LOISEAU, PM

GAYRAL, P

机构：

[1] FAC SCI CASABLANCA,DEPT BIOL,CASABLANCA,MOROCCO

[2] CHU RANGUEIL,PARASITOL & MYCOL LAB,F-31054 TOULOUSE,FRANCE

[3] FAC PHARM CHATENAY MALABRY,F-92290 CHATENAY MALABRY,FRANCE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 26卷 / 07期

关键词：

THIOUREINE; AMINO-ACID; GABA; NEMATODICID; ANTIFUNGIC;

D O I：

10.1016/0223-5234(91)90122-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Sixteen compounds, close to aryl or aralkylthioureines, with a beta-alanine or gamma-aminobutyric acid chain, were synthesized for in vitro screening towards 3 types of nematodes, 8 classes of opportunist germs and 34 classes of yeasts. Their anthelminthic activity was very weak, but on the other hand, 7 compounds were effective against yeasts and/or opportunist germs, with an MIC < 50-mu-g/ml.

引用

页码：723 / 727

页数：5

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