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EXPRESSION OF APHIDICOLIN-INDUCED FRAGILE SITES IN LYMPHOCYTES OF PATIENTS WITH BREAST-CANCER

被引：26
作者：
ARDISIA, C
VENTI, G
COLOZZA, MA
BRESCHI, C
PORFIRIO, B
DAVIS, S
TONATO, M
DONTI, E
机构：
[1] POLICLIN MONTELUCE,CITOGENET LAB,MED CLIN 1,I-06100 PERUGIA,ITALY
[2] UNIV PERUGIA,IST CLIN MED 1,I-06100 PERUGIA,ITALY
[3] POLICLIN MONTELUCE,DIV ONCOL,PERUGIA,ITALY
[4] UNIV FLORENCE,DIPARTIMENTO FISIOPATOL CLIN,SEZIONE GENET UMANA,I-50121 FLORENCE,ITALY
来源：
CANCER GENETICS AND CYTOGENETICS | 1993年 / 67卷 / 02期
关键词：
D O I：
10.1016/0165-4608(93)90162-F
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The expression of fragile sites induced by aphidicolin (APC) was evaluated on metaphase chromosomes obtained from the peripheral blood lymphocytes of 26 women with breast cancer and 15 sex- and age-matched normal controls. Both the proportion of damaged cells (P < 0.001) and the mean number of gaps and breaks per cell (0.02 < P < 0.05) were significantly higher in the patient group. There were no differences in either the age-related fragile site levels or the expression of single fragile sites between patients and controls. Our findings indicate an increased genetic instability in women with breast carcinoma.
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页码：113 / 116
页数：4
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