NUCLEOSIDES AND NUCLEOTIDES .118. SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING A NOVEL 2'-DEOXYURIDINE ANALOG THAT CARRIES AN AMINOALKYL TETHER AT 1'-POSITION - STABILIZATION OF DUPLEX FORMATION BY AN INTERCALATING GROUP ACCOMMODATED IN THE MINOR GROOVE

被引：21

作者：

DAN, A ^{[1
]}

YOSHIMURA, Y ^{[1
]}

ONO, A ^{[1
]}

MATSUDA, A ^{[1
]}

机构：

[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,KITA 12,NISHI 6,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期

关键词：

OLIGONUCLEOTIDE; OLIGONUCLEOTIDE SYNTHESIS; LINKER; MINOR GROOVE; INTERCALATOR; THERMAL DENATURATION;

D O I：

10.1016/S0960-894X(01)81240-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel 2'-deoxyuridine analogue carrying an aminoalkyl tether at l'-position of the sugar moiety was synthesized and incorporated into oligonucleotides, then an intercalating group was attached to the amino group. Duplexes, consisting of the oligonticleotides and a complementary strand. were more stable than a unmodified parent duplex.

引用

页码：615 / 618

页数：4

共 10 条

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