CARCINOGENICITY STUDY OF FECAPENTAENE-12 DIACETATE ON SKIN PAINTING IN SENCAR MICE

被引：4

作者：

DEVOR, DE

HENNEMAN, JR

KEEFER, LK

LOGSDON, DL

RICE, JM

STREETER, AJ

WARD, JM

机构：

[1] NCI,FREDERICK CANC RES & DEV CTR,COMPARAT CARCINOGENESIS LAB,FREDERICK,MD 21702

[2] NCI,FREDERICK CANC RES & DEV CTR,PRI DYNCORP,ANIM SCI PROGRAM,FREDERICK,MD 21702

[3] NCI,FREDERICK CANC RES & DEV CTR,PRI DYNCORP,BIOL CARCINOGENESIS LAB,FREDERICK,MD 21702

来源：

CANCER LETTERS | 1991年 / 56卷 / 01期

关键词：

FECAPENTAENE-12; DIACETATE; TUMOR INITIATION STUDY; ALPHA-TOCOPHEROL;

D O I：

10.1016/0304-3835(91)90187-M

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To investigate the effects of both diol esterification and coadministration with antioxidant on the tumorigenicity of fecapentaene-12 (FP-12) preparations, diacetylfecapentaene-12 (DAFP-12) in dimethylsulfoxide (DMSO) was applied to SENCAR mouse skin with or without the stabilizer, vitamin E, twice/week for 5 weeks, following which all animals were promoted for up to 25 weeks by weekly applications of 12-O-tetradecanoylphorbol-13-acetate (TPA). While positive controls receiving 7,12-dimethylbenz-[a]anthracene (DMBA) instead of DAFP-12 in a similar protocol all developed papillomas (average of 23/animal), papilloma incidence in mice given DAFP-12 did not differ significantly from that of the vehicle control. We conclude that DAFP-12 shows little or no tumor initiating activity for mouse skin even when coadministered with vitamin E.

引用

页码：11 / 15

页数：5

共 19 条

[1] FECAPENTAENE EXCRETION - ASPECTS OF EXCRETION IN NEWBORN-INFANTS, CHILDREN, AND ADULT NORMAL SUBJECTS AND IN ADULTS MAINTAINED ON TOTAL PARENTERAL-NUTRITION [J].