THE ANTINEOPLASTIC AND CYTOTOXICITY OF BENZOHYDROXAMIC ACIDS AND RELATED DERIVATIVES IN MURINE AND HUMAN TUMOR-CELLS

被引：9

作者：

HALL, IH ^{[1
]}

IZYDORE, R ^{[1
]}

HALL, ES ^{[1
]}

MILLER, MC ^{[1
]}

DANIELS, DL ^{[1
]}

DEBNATH, ML ^{[1
]}

WOODARD, T ^{[1
]}

机构：

[1] N CAROLINA CENT UNIV,DEPT CHEM,DURHAM,NC 27707

来源：

ANTI-CANCER DRUGS | 1992年 / 3卷 / 03期

关键词：

ANTINEOPLASTIC AGENTS; BENZOHYDROXAMIC ACIDS; DNA SYNTHESIS INHIBITORS; LEUKEMIA;

D O I：

10.1097/00001813-199206000-00011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Benzohydroxamic acids proved to be potent cytotoxic agents suppressing the growth of a number of murine and human cell lines grown in tissue culture, e.g. leukemia, colon, uterine and glioma. Selected compounds demonstrated activity against the growth KB nasopharynx, bronchogenic lung, osteosarcoma and skin cancer. In vivo activity against Ehrlich ascites carcinoma growth was shown with certain compounds. In L1210 cells compound 2 inhibited DNA synthesis significantly within 60 min. The site of action of the agent appears to involve the purine de novo synthesis pathway at PRPP amido transferase and IMP dehydrogenase. Dihydrofolate reductase and nucleoside kinase activities were inhibited by the agent. The levels of d(NTP)s in L1210 cells were reduced after drug treatment. The drug did not appear to affect the DNA template directly causing any damage which might alter transcription and replication nor was there any inhibition of HeLa topoisomerase activity by the drug. Thus the drug appears to be a metabolic inhibitor of nucleoside metabolism.

引用

页码：273 / 280

页数：8

共 41 条

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