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SYNTHESIS OF 3-ALPHA-ALKOXY-4-BETA-SUBSTITUTED-2-AZETIDINONES FROM L(+)-TARTARIC ACID

被引：5
作者：
BARTON, DHR
CLEOPHAX, J
GATEAUOLESKER, A
GERO, SD
TACHDJIAN, C
机构：
[1] INST CHIM SUBST NAT,CNRS,F-91198 GIF SUR YVETTE,FRANCE
[2] TEXAS A&M UNIV SYST,DEPT CHEM,COLL STN,TX 77843
来源：
TETRAHEDRON | 1993年 / 49卷 / 37期
关键词：
TARTARIC ACID; REGIOSELECTIVE SAPONIFICATION; PIG LIVER ESTERASE; 3-METHOXY-2-AZETIDINONE; N-HYDROXY-2-THIOPYRIDONE; RADICAL DECARBOXYLATION;
D O I：
10.1016/S0040-4020(01)81921-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of 3alpha-alkoxy-4beta-azetidinones from L(+) tartaric acid is described. Regioselective saponification and methylation along with a stereo selective radical decarboxylative alkylation are key steps leading to optically pure trans-beta-lactams.
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页码：8381 / 8396
页数：16
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