FLUORIDE REVERSIBLY BLOCKS HVA CALCIUM CURRENT IN MAMMALIAN THALAMIC NEURONS

被引：13

作者：

BERTOLLINI, L

BIELLA, G

WANKE, E

AVANZINI, G

DECURTIS, M

机构：

[1] IST NAZL NEUROL,DIPARTIMENTO NEUROFISIOL,I-20133 MILAN,ITALY

[2] UNIV MILAN,DIPARTIMENTO BIOCHIM & FISIOL GEN,MILAN,ITALY

来源：

NEUROREPORT | 1994年 / 5卷 / 05期

关键词：

CALCIUM CURRENTS; HVA; LVA; RAT; THALAMOCORTICAL NEURONS; WHOLE-CELL RECORDINGS;

D O I：

10.1097/00001756-199401000-00005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE effect of intracellular fluoride ions on voltage-dependent calcium currents was tested during whole-cell voltage-clamp recordings in thalamic neurones acutely dissociated from young adult rats. It is demonstrated that 5-30 mM intracellular fluoride selectively and reversibly suppresses the high voltage-activated, dihydropyridine-sensitive calcium current, without affecting the transient, low voltage-activated calcium current. Intracellular diffusion of a fluoride-free solution restores the blocking effect on the slow inactivating current induced by a transitory fluoride perfusion obtained by filling the patch microelectrode tip with caesium fluoride.

引用

页码：553 / 556

页数：4

共 18 条

[1] 2 KINDS OF CALCIUM CHANNELS IN CANINE ATRIAL CELLS - DIFFERENCES IN KINETICS, SELECTIVITY AND PHARMACOLOGY [J].