GINSENOSIDES EVOKE ENDOTHELIUM-DEPENDENT VASCULAR RELAXATION IN RAT AORTA

被引：78

作者：

KIM, ND ^{[1
]}

KANG, SY ^{[1
]}

SCHINI, VB ^{[1
]}

机构：

[1] UNIV FRANKFURT KLINIKUM, ZENTRUM PHYSIOL, D-60590 FRANKFURT, GERMANY

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1994年 / 25卷 / 06期

关键词：

D O I：

10.1016/0306-3623(94)90121-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Ginsenoside(10-100 mg/kg, i.v.) lowered blood pressure in a dose-dependent manner in rats. 2. Ginsenoside (10(-5)-3 x 10(-4) g/ml) relaxed the aorta after contractions were induced by 10(-6) M phenylephrine in the aorta with endothelium but not in that without endothelium. 3. The relaxation induced by ginsenoside was attenuated by 3 x 10(-7) M methylene blue (MB) and 10(-4) M N-G-monomethyl-L-arginine (L-NMMA) but not inhibited by 10(-5) M indomethacin. 4. Ginsenoside (10(-4) g/ml for 2 min) increased the accumulation of cGMP in rings with endothelium. L-NMMA and MB inhibited the accumulation of cGMP induced by ginsenoside. 5. These data suggest that vascular relaxations induced by ginsenoside are mediated by release of endothelium-drived nitric oxide which enhances the accumulation of cGMP.

引用

页码：1071 / 1077

页数：7

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