NEW-PROTEIN FUNCTIONS IN YEAST CHROMOSOME-VIII

被引：29

作者：

OUZOUNIS, C ^{[1
]}

BORK, P ^{[1
]}

CASARI, G ^{[1
]}

SANDER, C ^{[1
]}

机构：

[1] EUROPEAN MOLEC BIOL LAB,D-69012 HEIDELBERG,GERMANY

来源：

PROTEIN SCIENCE | 1995年 / 4卷 / 11期

关键词：

COMPUTATIONAL SEQUENCE ANALYSIS; FUNCTION PREDICTION; GENOME EVOLUTION; TRANSLATION FACTORS; YEAST GENOME;

D O I：

10.1002/pro.5560041121

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The analysis of the 269 open reading frames of yeast chromosome VIII by computational methods has yielded 24 new significant sequence similarities to proteins of known function. The resulting predicted functions include three particularly interesting cases of translation-associated proteins: peptidyl-tRNA hydrolase, a ribosome recycling factor homologue, and a protein similar to cytochrome b translational activator CBS2. The methodological limits of the meaningful transfer of functional information between distant homologues are discussed.

引用

页码：2424 / 2428

页数：5

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