IMMUNOELECTRON MICROSCOPIC LOCALIZATION OF AMYLOID BETA-PROTEIN IN THE DIFFUSE PLAQUES OF ALZHEIMER-TYPE DEMENTIA

被引：68

作者：

YAMAGUCHI, H

NAKAZATO, Y

HIRAI, S

SHOJI, M

机构：

[1] GUNMA UNIV,SCH MED,DEPT NEUROL,MAEBASHI,GUNMA 371,JAPAN

[2] GUNMA UNIV,SCH MED,DEPT PATHOL 1,MAEBASHI,GUNMA 371,JAPAN

来源：

BRAIN RESEARCH | 1990年 / 508卷 / 02期

关键词：

Alzheimer-type dementia; Amyloid; Coated vesicle; Immunoelectron microscopy; Senile plaque; β-Protein;

D O I：

10.1016/0006-8993(90)90416-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the ultrastructural localization of β protein in diffuse plaques of Alzheimer brain by indirect immunoperoxidase technique. Intense immunoreaction products, scattered sporadically in the diffuse plaques, were located on small bundles of several amyloid fibrils and/or amorphous materials between amyloid-related cell processes (ARCP). Deposits of β protein were also seen on parts of the cell membrane of ARCP, suggesting the importance of ARCP in plaque amyloid deposits. © 1990.

引用

页码：320 / 324

页数：5

共 23 条

[1] LOCALIZATION OF AMYLOID BETA-PROTEIN MESSENGER-RNA IN BRAINS FROM PATIENTS WITH ALZHEIMERS-DISEASE
BAHMANYAR, S
HIGGINS, GA
GOLDGABER, D
LEWIS, DA
MORRISON, JH
WILSON, MC
SHANKAR, SK
GAJDUSEK, DC
[J]. SCIENCE, 1987, 237 (4810) : 77 - 80
[2] ASSOCIATION BETWEEN QUANTITATIVE MEASURES OF DEMENTIA AND OF SENILE CHANGE IN CEREBRAL GREY MATTER OF ELDERLY SUBJECTS
BLESSED, G
TOMLINSON, BE
ROTH, M
[J]. BRITISH JOURNAL OF PSYCHIATRY, 1968, 114 (512) : 797 - +
[3] IMMUNOCYTOCHEMICAL LOCALIZATION OF THE PRECURSOR PROTEIN FOR BETA-AMYLOID IN THE RAT CENTRAL NERVOUS-SYSTEM
CARD, JP
MEADE, RP
DAVIS, LG
[J]. NEURON, 1988, 1 (09) : 835 - 846
[4] ALZHEIMERS-DISEASE - INITIAL REPORT OF THE PURIFICATION AND CHARACTERIZATION OF A NOVEL CEREBROVASCULAR AMYLOID PROTEIN
GLENNER, GG
WONG, CW
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (03) : 885 - 890
[5] SENILE PLAQUE-LIKE STRUCTURES - OBSERVATION OF A PROBABLY UNKNOWN TYPE OF SENILE PLAQUE BY PERIODIC-ACID METHENAMINE SILVER (PAM) ELECTRON-MICROSCOPY
IKEDA, K
HAGA, C
KOSAKA, K
OYANAGI, S
[J]. ACTA NEUROPATHOLOGICA, 1989, 78 (02) : 137 - 142
[6] IKEDA S, 1987, LAB INVEST, V57, P446
[7] THE PRECURSOR OF ALZHEIMERS-DISEASE AMYLOID-A4 PROTEIN RESEMBLES A CELL-SURFACE RECEPTOR
KANG, J
LEMAIRE, HG
UNTERBECK, A
SALBAUM, JM
MASTERS, CL
GRZESCHIK, KH
MULTHAUP, G
BEYREUTHER, K
MULLERHILL, B
[J]. NATURE, 1987, 325 (6106) : 733 - 736
[8] DIAGNOSIS OF ALZHEIMERS-DISEASE
KHACHATURIAN, ZS
[J]. ARCHIVES OF NEUROLOGY, 1985, 42 (11) : 1097 - 1104
[9] KITAMOTO T, 1987, LAB INVEST, V57, P230
[10] DISTRIBUTION OF PRECURSOR AMYLOID-BETA-PROTEIN MESSENGER-RNA IN HUMAN CEREBRAL-CORTEX - RELATIONSHIP TO NEUROFIBRILLARY TANGLES AND NEURITIC PLAQUES
LEWIS, DA
HIGGINS, GA
YOUNG, WG
GOLDGABER, D
GAJDUSEK, DC
WILSON, MC
MORRISON, JH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (05) : 1691 - 1695

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