STEREOSELECTIVE CONJUGATE ADDITION OF TMSI-ACTIVATED BUTYLCOPPER TO 1-(R)-ENDO-(1-NAPHTHYL)BORNYL CROTONATE

被引：17

作者：

BERGDAHL, M

NILSSON, M

OLSSON, T

机构：

[1] Department of Organic Chemistry Chalmers University of Technology

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 1990年 / 391卷 / 02期

关键词：

D O I：

10.1016/0022-328X(90)80182-Y

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Conjugate addition of butylcopper/iodotrimethylsilane to naphthylbornyl crotonate (1) at -60°C gives 1-[1-(R)-endo-(1-naphthyl)]bornyl [(S)-3-methyl]-heptanoate (2) in 93% yield and 98% diastereomeric excess. The addition of TMSI-activated butylcopper is faster at -60°C than that of lithium dibutylcuprate (LiBu2Cu). © 1990.

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页码：C19 / C22

页数：4

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