DELTORPHIN, A NATURALLY-OCCURRING PEPTIDE WITH HIGH SELECTIVITY FOR DELTA-OPIOID RECEPTORS, IMPROVES MEMORY CONSOLIDATION IN 2 INBRED STRAINS OF MICE

被引：27

作者：

PAVONE, F

POPULIN, R

CASTELLANO, C

KREIL, G

MELCHIORRI, P

机构：

[1] UNIV LA SAPIENZA,INST PHARMACOL,I-00185 ROME,ITALY

[2] AUSTRIAN ACAD SCI,INST MOLEC BIOL,A-5020 SALZBURG,AUSTRIA

来源：

PEPTIDES | 1990年 / 11卷 / 03期

关键词：

Amphibian peptide; C57BL/6; mice; DBA/2; Deltorphin; One-trial inhibitory avoidance;

D O I：

10.1016/0196-9781(90)90063-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deltorphin, a heptapeptide that selectively binds to δ receptors, was intracerebroventricularly administered to mice belonging to the strains C57BL/6 and DBA/2 immediately after training in a one-trial inhibitory avoidance task. The retention performance of both strains was improved by the peptide administration, with DBA mice being more sensitive to this effect. The results show different effects of δ and μ receptor agonists on memory consolidation and of strain differences in number and/or distribution of δ opioid receptors in the brain. © 1990.

引用

页码：591 / 594

页数：4

共 22 条

[1]

BELLUZZI JD, 1977, SOC NEUR ABSTR, V3, P230

[2]

BELLUZZI JD, 1981, ENDOGENOUS PEPTIDES, P291

[3] STRAIN-DEPENDENT EFFECTS OF NALOXONE ON DISCRIMINATION-LEARNING IN MICE [J].