AN INVESTIGATION OF THE EFFECT OF HIGH-SPEED MIXING ON THE MECHANICAL AND PHYSICAL-PROPERTIES OF DIRECT COMPRESSION LACTOSE

被引：5

作者：

THWAITES, PM

MASHADI, AB

MOORE, WD

机构：

[1] Development Laboratories, Merck Sharp and Dohme, Hoddesdon, England

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1991年 / 17卷 / 04期

关键词：

D O I：

10.3109/03639049109044259

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effect of high speed mixing on the mechanical and physical properties of four commercially available grades of direct compression lactose is considered. The changes that are evidenced in these properties are found to be specific to each grade of lactose and it is recommended that due consideration be given to the effects of incorporating such a process if interbatch tablet variation is to be avoided.

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页码：503 / 517

页数：15

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