PINACIDIL INHIBITS THE RYANODINE-SENSITIVE OUTWARD CURRENT AND GLIBENCLAMIDE ANTAGONIZES ITS ACTION IN CELLS FROM THE RABBIT PORTAL-VEIN

被引：24

作者：

XIONG, ZL ^{[1
]}

KAJIOKA, S ^{[1
]}

SAKAI, T ^{[1
]}

KITAMURA, K ^{[1
]}

KURIYAMA, H ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC MED,DEPT PHARMACOL,FUKUOKA 812,JAPAN

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1991年 / 102卷 / 04期

关键词：

PINACIDIL; GLIBENCLAMIDE; CA-DEPENDENT K-CURRENT; OSCILLATORY OUTWARD CURRENT; CA RELEASE; INTRACELLULAR CA STORE SITES; K-CHANNEL OPENER; ATP-SENSITIVE K-CHANNEL;

D O I：

10.1111/j.1476-5381.1991.tb12252.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pinacidil, a potassium-channel opener, inhibited the ryanodine-sensitive oscillatory outward potassium current induced by Ca released from an intracellular store. Glibenclamide, a blocker of the ATP-sensitive K-channel, prevented the action of pinacidil, suggesting the presence of an additional site (to K channels) for the vasodilator actions of pinacidil at which glibenclamide can act as an antagonist.

引用

页码：788 / 790

页数：3

共 10 条

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