SACCHARIN EFFECTS ON MORPHINE-INDUCED TEMPERATURE-CHANGES IN RATS

被引：5

作者：

BOWERS, RL

NICASTLE, LD

FALB, DC

机构：

[1] Department of Psychology, University of Charleston, Charleston

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1993年 / 46卷 / 02期

基金：

美国国家科学基金会;

关键词：

SACCHARIN; MORPHINE; TEMPERATURE; ENDOGENOUS OPIOIDS; RATS;

D O I：

10.1016/0091-3057(93)90384-6

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of saccharin on morphine-induced temperature change was examined in Long-Evans rats. Rats were given free access to 0.15% saccharin for 15 days, followed by saccharin deprivation for 9 days. Saccharin was then returned to one group, while a second group received water. All rats were then injected with morphine sulfate (2 mg/kg), and postinjection temperatures were assessed over 75 min. The results showed that saccharin enhanced the biphasic effects of morphine by significantly increasing the hypothermic phase. The findings support the view that sweet substances influence endogenous opioid release.

引用

页码：483 / 485

页数：3

共 14 条

[1] COMPONENTS OF THE OPIOID WITHDRAWAL SYNDROME IN MICE ARE THERMOREGULATORY RESPONSES [J].