AUTOANTIBODIES TO CRYPTIC EPITOPES OF C-REACTIVE PROTEIN AND OTHER ACUTE-PHASE PROTEINS IN THE TOXIC OIL SYNDROME

被引:26
作者
BELL, SA
DUCLOS, TW
KHURSIGARA, G
PICAZO, JJ
RUBIN, RL
机构
[1] Scripps Res Inst, RES INST, DEPT MOLEC & EXPTL MED, WM KECK AUTOIMMUNE DIS CTR, LA JOLLA, CA 92037 USA
[2] VET ADM MED CTR, ALBUQUERQUE, NM 87108 USA
[3] HOSP UNIV SAN CARLOS, MADRID, SPAIN
关键词
D O I
10.1006/jaut.1995.0022
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Toxic oil syndrome (TOS) was caused by the consumption of rapeseed oil contaminated with derivatives of aniline. Many persons who survived the acute phase developed a puzzling, multi-year chronic disease considered to be inflammatory or autoimmune in nature. In attempting to characterize their autoantibodies, we found that 74% of TOS patients with chronic disease had IgG antibodies to C-reactive protein (CRP), This activity was detectable only when CRP was chemically or physically denatured and behaved like a previously described antibody produced by immunization with the CRP monomer. Significant antibody reactivities to other acute phase proteins, especially alpha(1)-antitrypsin and fibrinogen (P<0.025) and ceruloplasmin (P<0.05) were also observed. IgG antibodies to cryptic epitopes in CRP and other major serum proteins that increase during the acute phase response may reflect an earlier toxin-mediated insult to the liver that included abnormal biosynthesis of and/or damage to acute phase proteins.
引用
收藏
页码:293 / 303
页数:11
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