DENGUE VIRUS-SPECIFIC MEMORY T-CELL RESPONSES IN HUMAN VOLUNTEERS RECEIVING A LIVE ATTENUATED DENGUE VIRUS TYPE-2 CANDIDATE VACCINE

被引：48

作者：

DHARAKUL, T

KURANE, I

BHAMARAPRAVATI, N

YOKSAN, S

VAUGHN, DW

HOKE, CH

ENNIS, FA

机构：

[1] UNIV MASSACHUSETTS,MED CTR,DEPT MED,DIV INFECT DIS & IMMUNOL,WORCESTER,MA 01655

[2] MAHIDOL UNIV,SIRIRAJ HOSP,FAC MED,DEPT MICROBIOL,DIV IMMUNOL,BANGKOK,THAILAND

[3] MAHIDOL UNIV,CTR VACCINE DEV,INST SCI & TECHNOL DEV,NAKHON PATHOM,THAILAND

[4] WALTER REED ARMY INST RES,DEPT VIRUS DIS,WASHINGTON,DC

来源：

JOURNAL OF INFECTIOUS DISEASES | 1994年 / 170卷 / 01期

关键词：

D O I：

10.1093/infdis/170.1.27

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A live attenuated dengue virus type 2 candidate vaccine (16681-PDK53) was evaluated in a phase I trial in 10 nonimmune adult volunteers. The dengue virus-specific memory T cell responses were analyzed as part of this study. Dengue virus-specific T cell proliferative responses were observed in all subjects after stimulating their peripheral blood mononuclear cells with live viruses or noninfectious viral antigens. The highest proliferative response was against dengue virus type 2, although cross-reactivity with other flaviviruses was detected to a lesser degree in some subjects. Dengue virus type 2-specific CD4(+) and CD8(+) cytotoxic T lymphocytes were generated in all vaccinees. This study investigated whether the candidate vaccine was efficacious in inducing dengue virus-specific CD4(+) and CD8(+) T cell memory after a single immunization in nonimmune recipients.

引用

页码：27 / 33

页数：7

共 11 条

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