ENDOTHELIN-1-INDUCED PHOSPHORYLATION OF THE 20-KDA MYOSIN LIGHT CHAIN AND CALDESMON IN PORCINE CORONARY-ARTERY SMOOTH-MUSCLE

被引：20

作者：

ABE, Y

KASUYA, Y

KUDO, M

YAMASHITA, K

GOTO, K

MASAKI, T

TAKUWA, Y

机构：

[1] UNIV TSUKUBA,SCH MED,DEPT INTERNAL MED,TSUKUBA,IBARAKI 305,JAPAN

[2] UNIV TSUKUBA,SCH MED,DEPT PHARMACOL,TSUKUBA,IBARAKI 305,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1991年 / 57卷 / 03期

关键词：

D O I：

10.1254/jjp.57.431

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Endothelin-1 (ET), a potent vasconstrictor, induces a sustained increase in the phosphorylation level of the 20-kDa myosin light chain (MLC) in porcine coronary artery strips. ET also induces late phosphorylation of caldesmon, which is mimicked by 12-deoxyphorbol 13-isobutyrate, but not by 60 mM KCl. Nitroglycerin, a vasorelaxant, completely reverses the ET-induced phosphorlylation of MLC, but not that of caldesmon. These results suggest an important regulatory role of MLC phosphorylation in ET-induced contraction.

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收藏

页码：431 / 435

页数：5

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