HEPATOCYTES IN PRIMARY CULTURE BECOME SUSCEPTIBLE TO PARACETAMOL INJURY AFTER DEPLETION OF GLUTATHIONE USING DL-BUTHIONINE-SR-SULFOXIMINE (BSO)

被引：18

作者：

HUE, DP

GRIFFITH, KL

MCLEAN, AEM

机构：

来源：

BIOCHEMICAL PHARMACOLOGY | 1985年 / 34卷 / 24期

关键词：

D O I：

10.1016/0006-2952(85)90298-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

收藏

页码：4341 / 4344

页数：4

相关论文

共 8 条

[1] CYTO-TOXICITY OF ACETAMINOPHEN AND PAPAVERINE IN PRIMARY CULTURES OF RAT HEPATOCYTES [J].

ACOSTA, D ;

ANUFORO, DC ;

SMITH, RV .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1980, 53 (02) :306-314

[2] LIPID-PEROXIDATION, PROTEIN-SYNTHESIS, AND PROTECTION BY CALCIUM EDTA IN PARACETAMOL INJURY TO ISOLATED HEPATOCYTES [J].

BEALES, D ;

HUE, DP ;

MCLEAN, AEM .

BIOCHEMICAL PHARMACOLOGY, 1985, 34 (01) :19-23

[3] DISSOCIATION OF CELL-DEATH FROM COVALENT BINDING OF PARACETAMOL BY FLAVONES IN A HEPATOCYTE SYSTEM [J].

DEVALIA, JL ;

OGILVIE, RC ;

MCLEAN, AEM .

BIOCHEMICAL PHARMACOLOGY, 1982, 31 (23) :3745-3749

[4]

GRIFFITH OW, 1979, J BIOL CHEM, V254, P7558

[5] DETERMINATION OF GLUTATHIONE AND GLUTATHIONE DISULFIDE USING GLUTATHIONE-REDUCTASE AND 2-VINYLPYRIDINE [J].

GRIFFITH, OW .

ANALYTICAL BIOCHEMISTRY, 1980, 106 (01) :207-212

[6]

Moldeus P, 1978, Methods Enzymol, V52, P60

[7] PARACETAMOL METABOLISM AND TOXICITY IN ISOLATED HEPATOCYTES FROM RAT AND MOUSE [J].

MOLDEUS, P .

BIOCHEMICAL PHARMACOLOGY, 1978, 27 (24) :2859-2863

[8]

RICHARDS GM, 1974, ANAL BIOCHEM, V57, P36