MOUSE MODELS OF HUMAN SINGLE GENE DISORDERS .1. NONTRANSGENIC MICE

被引：23

作者：

DARLING, SM ^{[1
]}

ABBOTT, CM ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL,DEPT GENET & BIOMETRY,LONDON NW1 2HE,ENGLAND

来源：

BIOESSAYS | 1992年 / 14卷 / 06期

关键词：

D O I：

10.1002/bies.950140602

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mouse models of human genetic disorders provide a valuable resource for investigating the pathogenesis of genetic disease and for testing potential therapies. The high degree of resolution of linkage mapping in the mouse allows mutant phenotypes to be mapped precisely which, combined with the accurate definition of areas of homology between the mouse and human genomes, greatly facilitates the identification of mouse models. We describe here mouse models of human single gene disorders dividing them into three categories depending on the information available; phenotypic similarities, comparative mapping and identification of the underlying genetic lesion.

引用

页码：359 / 366

页数：8

共 59 条

[51] LOCALIZATION OF CHARCOT-MARIE-TOOTH DISEASE TYPE-1A (CMT1A) TO CHROMOSOME 17P11.2 [J].

VANCE, JM ;

BARKER, D ;

YAMAOKA, LH ;

STAJICH, JM ;

LOPREST, L ;

HUNG, WY ;

FISCHBECK, K ;

ROSES, AD ;

PERICAKVANCE, MA .

GENOMICS, 1991, 9 (04) :623-628

[52] LOCATION OF THE GENE INVOLVING THE SMALL EYE MUTATION ON MOUSE CHROMOSOME-2 SUGGESTS HOMOLOGY WITH HUMAN ANIRIDIA-2 (AN2) [J].

VANDERMEERDEJONG, R ;

DICKINSON, ME ;

WOYCHIK, RP ;

STUBBS, L ;

HETHERINGTON, C ;

HOGAN, BLM .

GENOMICS, 1990, 7 (02) :270-275

[53] GLI3 ZINC-FINGER GENE INTERRUPTED BY TRANSLOCATIONS IN GREIG SYNDROME FAMILIES [J].

VORTKAMP, A ;

GESSLER, M ;

GRZESCHIK, KH .

NATURE, 1991, 352 (6335) :539-540

[54] BONE-RESORPTION RESTORED IN OSTEOPETROTIC MICE BY TRANSPLANTS OF NORMAL BONE-MARROW AND SPLEEN-CELLS [J].

WALKER, DG .

SCIENCE, 1975, 190 (4216) :784-785

[55] GENE-THERAPY IN PERSPECTIVE [J].

WEATHERALL, DJ .

NATURE, 1991, 349 (6307) :275-276

[56] ANKYRIN AND THE HEMOLYTIC-ANEMIA MUTATION, NB, MAP TO MOUSE CHROMOSOME-8 - PRESENCE OF THE NB ALLELE IS ASSOCIATED WITH A TRUNCATED ERYTHROCYTE ANKYRIN [J].

WHITE, RA ;

BIRKENMEIER, CS ;

LUX, SE ;

BARKER, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :3117-3121

[57] THE GONADOTROPIN-RELEASING-HORMONE (GNRH) GENE MAPS TO MOUSE CHROMOSOME-14 AND IDENTIFIES A HOMOLOGOUS REGION ON HUMAN CHROMOSOME-8 [J].

WILLIAMSON, P ;

LANG, J ;

BOYD, Y .

SOMATIC CELL AND MOLECULAR GENETICS, 1991, 17 (06) :609-615

[58] MALFORMATION SYNDROMES - A REVIEW OF MOUSE HUMAN HOMOLOGY [J].

WINTER, RM .

JOURNAL OF MEDICAL GENETICS, 1988, 25 (07) :480-487

[59]

ZLOTOGORA J, 1990, AM J HUM GENET, V47, P37

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