GINSENOSIDE RG(1) INHIBITS THE BRAIN CAMP-PHOSPHODIESTERASE ACTIVITY IN YOUNG AND AGED RATS

被引：18

作者：

STANCHEVA, SL

ALOVA, LG

机构：

[1] Department of Experimental Pharmacology, Institute of Physiology, Bulgarian Academy of Sciences, 1113 Sofia

来源：

GENERAL PHARMACOLOGY | 1993年 / 24卷 / 06期

关键词：

D O I：

10.1016/0306-3623(93)90435-Z

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The in vitro effect of ginsenoside Rg1 from Panax ginseng on the low- and high-K(M) cyclic AMP phosphodiesterase (cAMP PDE) activity in the frontal cortex, striatum, hypothalamus and hippocampus of young (4-5-month old) and aged (22-month old) rats has been studied. 2. Administered in increasing concentrations (from 5 x 10(-5) M Up to 5 X 10(-4) M), ginsenoside Rg1 exerted a pronounced inhibitory effect on the low- and high-K(M) enzyme activity in all brain structures studied in rats of both age groups. 3. Ginsenoside Rg1 exhibited inhibitory potency similar to that of theophylline. 4. The present results provide evidence for the CNS effects of ginsenoside Rg1 through inhibition of the intracellular level of cAMP.

引用

页码：1459 / 1462

页数：4

共 20 条

[1]

BARTUS RT, 1981, STRATEGIES DEV EFFEC, P71

[2]

BRANCONNIER RJ, 1986, INT ENCY PHARM THERA, P421

[3] BRAIN NEUROTRANSMITTERS IN AGING AND DEMENTIA - SIMILAR CHANGES ACROSS DIAGNOSTIC DEMENTIA GROUPS [J].

CARLSSON, A .

GERONTOLOGY, 1987, 33 (3-4) :159-167

[4] THE RELATIONSHIP BETWEEN STEREOTYPY AND MEMORY IMPROVEMENT PRODUCED BY AMPHETAMINE [J].

CARR, GD ;

WHITE, NM .

PSYCHOPHARMACOLOGY, 1984, 82 (03) :203-209

[5] ISOTOPIC ASSAY OF CYCLIC 3',5'-NUCLEOTIDE PHOSPHODIESTERASE WITHALUMINUM OXIDE COLUMNS [J].

FILBURN, CR ;

KARN, J .

ANALYTICAL BIOCHEMISTRY, 1973, 52 (02) :505-516

[6] SELECTIVE IMPAIRMENT OF PAIRED-ASSOCIATE LEARNING AFTER ADMINISTRATION OF A CENTRALLY-ACTING ADRENERGIC AGONIST (CLONIDINE) [J].

FRITH, CD ;

DOWDY, J ;

FERRIER, IN ;

CROW, TJ .

PSYCHOPHARMACOLOGY, 1985, 87 (04) :490-493

[7]

HIAI S, 1979, ENDOCRINOL JAPON, V26, P661

[8]

JUNTIAN Z, 1989, INT GINSENG SEMINAR, P31

[9]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[10]

ODANI T, 1985, PLANTA MED, P177

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