AN APPROACH TO VECTORIZATION OF PHARMACOLOGICALLY ACTIVE MOLECULES - THE COVALENT BINDING OF LEU-ENKEPHALIN TO A MODIFIED BETA-CYCLODEXTRIN

被引：40

作者：

PARROTLOPEZ, H

DJEDAINI, F

PERLY, B

COLEMAN, AW

GALONS, H

MIOCQUE, M

机构：

[1] CENS,SERV CHIM MOLEC,F-91191 GIF SUR YVETTE,FRANCE

[2] UNIV PARIS 05,CHIM ORGAN LAB 3,F-75006 PARIS,FRANCE

[3] UNIV PARIS SUD,CNRS,UNITE ASSOCIEE 496,F-92260 CHATENAY MALABRY,FRANCE

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(00)88899-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The neurotropic peptide Leu-enkephalin has been coupled to a mono-6-amino permethyl βcyclodextrin at the C-terminal residue. The resulting compound has been fully characterized by proton NMR in D2O and d6-DMSO evidencing complete reduction of the molecular symmetry of the cyclodextrin. © 1990.

引用

页码：1999 / 2002

页数：4

共 7 条

[1] SELECTION OF COHERENCE-TRANSFER PATHWAYS IN NMR PULSE EXPERIMENTS [J].