RACEMIZED D-ASPARTATE IN ALZHEIMER NEUROFIBRILLARY TANGLES

被引：37

作者：

FISHER, GH

PAYAN, IL

CHOU, SJ

MAN, EH

CERWINSKI, S

MARTIN, T

EMORY, C

FREY, WH

机构：

[1] UNIV MIAMI,DEPT CHEM,CORAL GABLES,FL 33124

[2] ST PAUL RAMSEY MED CTR,RAMSEY CLIN,CTR ALZHEIMERS TREATMENT & RES,ST PAUL,MN 55101

来源：

BRAIN RESEARCH BULLETIN | 1992年 / 28卷 / 01期

关键词：

D-ASPARTATE; D-ASP; ALZHEIMERS DISEASE; NEUROFIBRILLARY TANGLES; HUMAN BRAIN;

D O I：

10.1016/0361-9230(92)90239-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Normal protein-bound L-aspartyl/L-asparaginyl residues may undergo posttranslational modification by racemization to D-aspartate. Based on preliminary results reported here, proteins associated with Alzheimer neurofibrillary tangle preparations contain a greater number of these racemized D-aspartyl residues than the unaffected proteins from the surrounding gray matter or in comparable preparations from normal brains.

引用

页码：127 / 131

页数：5

共 21 条

[1] BADA JL, 1984, METHOD ENZYMOL, V106, P98
[2] CHASE TN, 1984, ANN NEUROL, V15, pS170
[3] PROTEIN CARBOXYL METHYLTRANSFERASES - 2 DISTINCT CLASSES OF ENZYMES
CLARKE, S
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1985, 54 : 479 - 506
[4] D-ASPARTIC ACID IN PURIFIED MYELIN AND MYELIN BASIC-PROTEIN
FISHER, GH
GARCIA, NM
PAYAN, IL
CADILLAPEREZRIOS, R
SHEREMATA, WA
MAN, EH
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 135 (02) : 683 - 687
[5] FREE D-ASPARTATE AND D-ALANINE IN NORMAL AND ALZHEIMER BRAIN
FISHER, GH
DANIELLO, A
VETERE, A
PADULA, L
CUSANO, GP
MAN, EH
[J]. BRAIN RESEARCH BULLETIN, 1991, 26 (06) : 983 - 985
[6] ANTIBODIES TO PAIRED HELICAL FILAMENTS IN ALZHEIMERS-DISEASE DO NOT RECOGNIZE NORMAL BRAIN PROTEINS
IHARA, Y
ABRAHAM, C
SELKOE, DJ
[J]. NATURE, 1983, 304 (5928) : 727 - 730
[7] ALZHEIMER PAIRED HELICAL FILAMENTS - BULK ISOLATION, SOLUBILITY, AND PROTEIN-COMPOSITION
IQBAL, K
ZAIDI, T
THOMPSON, CH
MERZ, PA
WISNIEWSKI, HM
[J]. ACTA NEUROPATHOLOGICA, 1984, 62 (03) : 167 - 177
[8] ALZHEIMERS-DISEASE
KATZMAN, R
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (15) : 964 - 973
[9] X-RAY-DIFFRACTION FROM INTRANEURONAL PAIRED HELICAL FILAMENTS AND EXTRANEURONAL AMYLOID FIBERS IN ALZHEIMER-DISEASE INDICATES CROSS-BETA CONFORMATION
KIRSCHNER, DA
ABRAHAM, C
SELKOE, DJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (02) : 503 - 507
[10] A68 - A MAJOR SUBUNIT OF PAIRED HELICAL FILAMENTS AND DERIVATIZED FORMS OF NORMAL-TAU
LEE, VMY
BALIN, BJ
OTVOS, L
TROJANOWSKI, JQ
[J]. SCIENCE, 1991, 251 (4994) : 675 - 678

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