AGE-RELATED-CHANGES OF MESSENGER-RNA EXPRESSION OF AMYLOID PRECURSOR PROTEIN IN THE BRAIN OF SENESCENCE-ACCELERATED MOUSE

被引：5

作者：

CHO, HS

KIM, SS

CHOI, W

KIM, SH

JEONG, SJ

HONG, R

CHONG, YH

LEE, YJ

PARK, CW

LEE, KW

SUH, YH

机构：

[1] SEOUL NATL UNIV, COLL MED, DEPT PHARMACOL, SEOUL 110799, SOUTH KOREA

[2] SEOUL NATL UNIV, COLL MED, DEPT NEUROL, SEOUL 110799, SOUTH KOREA

[3] SEOUL NATL UNIV, NEUROSCI RES INST, DEPT MOLEC BIOL, SEOUL 110799, SOUTH KOREA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1995年 / 112卷 / 02期

关键词：

AGING; AMYLOID PRECURSOR PROTEIN (APP); MESSENGER-RNA; SENESCENCE-ACCELERATED MOUSE; (SAM); BRAIN;

D O I：

10.1016/0305-0491(95)00090-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

APP695 mRNA is only expressed in the brains of SAM. The expression of APP mRNA in SAM P1 mice brains is more marked than that in SAM R1 mice brain. APP mRNA expression was increased with advancing age in all brain regions of SAM P1 mice compared with SAM R1, Especially, the changes of the amount of APP mRNA in the prosencephalon and the mesencephalon are significant at P value of 0.05. We suggest that overexpression of APP mRNA may be related to accelerated aging phenomenon in the SAM brain. This is the first report of age-related increase in the amount of APP mRNA in the SAM brain.

引用

收藏

页码：399 / 404

页数：6

相关论文

共 34 条

[1] ALPHA-1-ANTICHYMOTRYPSIN IS PRESENT TOGETHER WITH THE BETA-PROTEIN IN MONKEY BRAIN AMYLOID DEPOSITS [J].

ABRAHAM, CR ;

SELKOE, DJ ;

POTTER, H ;

PRICE, DL ;

CORK, LC .

NEUROSCIENCE, 1989, 32 (03) :715-720

[2] PERIODIC ACID-SCHIFF (PAS)-POSITIVE, ANTIGRANULOCYTES STRUCTURES INCREASE IN THE BRAIN OF SENESCENCE ACCELERATED MOUSE (SAM) [J].

AKIYAMA, H ;

KAMEYAMA, M ;

AKIGUCHI, I ;

SUGIYAMA, H ;

KAWAMATA, T ;

FUKUYAMA, H ;

KIMURA, H ;

MATSUSHITA, M ;

TAKEDA, T .

ACTA NEUROPATHOLOGICA, 1986, 72 (02) :124-129

[3] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].

CHIRGWIN, JM ;

PRZYBYLA, AE ;

MACDONALD, RJ ;

RUTTER, WJ .

BIOCHEMISTRY, 1979, 18 (24) :5294-5299

[4]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[5] A NOVEL MESSENGER-RNA OF THE A4-AMYLOID PRECURSOR GENE CODING FOR A POSSIBLY SECRETED PROTEIN [J].

DESAUVAGE, F ;

OCTAVE, JN .

SCIENCE, 1989, 245 (4918) :651-653

[6] CEREBRAL PREAMYLOID DEPOSITS AND CONGOPHILIC ANGIOPATHY IN AGED DOGS [J].

GIACCONE, G ;

VERGA, L ;

FINAZZI, M ;

POLLO, B ;

TAGLIAVINI, F ;

FRANGIONE, B ;

BUGIANI, O .

NEUROSCIENCE LETTERS, 1990, 114 (02) :178-183

[7] ALZHEIMERS-DISEASE - INITIAL REPORT OF THE PURIFICATION AND CHARACTERIZATION OF A NOVEL CEREBROVASCULAR AMYLOID PROTEIN [J].

GLENNER, GG ;

WONG, CW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (03) :885-890

[8] EXPRESSION OF BETA-AMYLOID PROTEIN-PRECURSOR MESSENGER-RNAS - RECOGNITION OF A NOVEL ALTERNATIVELY SPLICED FORM AND QUANTITATION IN ALZHEIMERS-DISEASE USING PCR [J].

GOLDE, TE ;

ESTUS, S ;

USIAK, M ;

YOUNKIN, LH ;

YOUNKIN, SG .

NEURON, 1990, 4 (02) :253-267

[9]

HIGUCHI K, 1986, J BIOL CHEM, V261, P2834

[10] GRADING SCORE SYSTEM - A METHOD FOR EVALUATION OF THE DEGREE OF SENESCENCE IN SENESCENCE ACCELERATED MOUSE (SAM) [J].

HOSOKAWA, M ;

KASAI, R ;

HIGUCHI, K ;

TAKESHITA, S ;

SHIMIZU, K ;

HAMAMOTO, H ;

HONMA, A ;

IRINO, M ;

TODA, K ;

MATSUMURA, A ;

MATSUSHITA, M ;

TAKEDA, T .

MECHANISMS OF AGEING AND DEVELOPMENT, 1984, 26 (01) :91-102

← 1 2 3 4 →