SYNTHESIS OF HOMOCHIRAL L-(S)-TERT-LEUCINE VIA A LIPASE-CATALYZED DYNAMIC RESOLUTION PROCESS

被引：80

作者：

TURNER, NJ ^{[1
]}

WINTERMAN, JR ^{[1
]}

MCCAGUE, R ^{[1
]}

PARRATT, JS ^{[1
]}

TAYLOR, SJC ^{[1
]}

机构：

[1] CHIROSCI LTD,CAMBRIDGE CB4 4WE,ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 07期

关键词：

D O I：

10.1016/0040-4039(94)02408-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of (+/-)-2-phenyl-4-tert-butyloxazolin-5(4H)-8 with Lipozyme(R) (Mucor miehei) in toluene containing n-butanol and a catalytic amount of triethylamine resulted in a 94% yield of (S)-N-benzoyl tert-leucine butyl ester 9 (99.5% e.e.). Subsequent two step hydrolysis (Alcalase(R) followed by 6N HCl, reflux) yielded homochiral L-(S)-tert-leucine 1.

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页码：1113 / 1116

页数：4

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