IMPROVED REFLOW AND VIABILITY IN REPERFUSED ISCHEMIC RAT ISLAND GROIN FLAPS USING DEXAMETHASONE

被引：13

作者：

DOLAN, RW

KERR, DC

ARENA, S

机构：

[1] Department of Otolaryngology, Mercy Hospital of Pittsburgh, Pittsburgh, Pennsylvania

来源：

MICROSURGERY | 1995年 / 16卷 / 02期

关键词：

D O I：

10.1002/micr.1920160208

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Reperfusion injury and the no-reflow phenomenon are manifestations of a complex series of events that culminate in an acute inflammatory reaction within reperfused tissue. Antiinflammatory therapy attenuates ischemia-reperfusion injury. The purpose of this study is to evaluate the effects of dexamethasone on blood flow and viability of ischemic rat island groin flaps. Thirty-three mature male Sprague-Dawley rats were divided into 3 groups. The flaps were subjected to 8 hr of ischemia in the control and treatment groups. Fluorescein studies were performed, and flap viability was assessed, Twenty-four hour fluorescence (after reperfusion) correlated very closely with the percentage of eventual flap viability, The blood flow and viability of the treatment group flaps were significantly better than those in the ischemic control group. Dexamethasone significantly improved ischemic flap survival in the rat 8 hr ischemic island groin flap model in our study. (C) 1995 Wiley-Liss, Inc.

引用

页码：86 / 89

页数：4

共 21 条

[1]

Fantone JC, Pathogenesis of ischemia‐reperfusion injury: An overview, pp. 137-145, (1990)

[2]

Hernandez LA, Grisham MB, Twohig B, Et al., Role of neutrophils in ischemia reperfusion‐induced microvascular injury, Am J Physiol, 253, pp. 699-703, (1987)

[3]

Vedder NB, Winn RK, Rice CL, Et al., A monoclonal antibody to the adherence‐promoting leukocyte glycoprotein, CD18, reduces organ injury, J Clin Invest, 81, pp. 939-944, (1988)

[4]

Del Maestro RF, Planker M, Arfors KE, Evidence for the participation of superoxide anion radical in altering the adhesive interaction between granulocytes and endothelium in vivo, Int J Microcirc Clin Exp, 1, pp. 105-120, (1982)

[5]

Lucchesi BR, Clinical Ischemic Syndromes, pp. 257-275, (1990)

[6]

Goisham MB, Hernandez LA, Granger DN, Xanthine oxidase and neutrophil infiltration in intestinal ischemia, Am J Physiol, 251, (1986)

[7]

Linas SL, Neutrophils accentuate ischemia‐reperfusion injury in isolated perfused rat kidneys, Am J Physiol, 255, (1988)

[8]

Korthuis RJ, Goisham MB, Granger DN, Leukocyte depletion attenuates vascular injury in postischemic skeletal muscle, Am J Physiol, 254, (1988)

[9]

Ferrari R, Importance of oxygen free radicals during ischemia and reperfusion in the experimental and clinical setting, Am J CV Pathol, 4, pp. 103-114, (1992)

[10]

Till GO, Friedl HP, Ward PA, Phagocytic cell‐mediated injury: relationship to ischemic injury, Clinical Ischemic Syndromes, pp. 327-345, (1990)

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