THE RAT ALPHA-2-C4 ADRENERGIC-RECEPTOR GENE ENCODES A NOVEL PHARMACOLOGICAL SUBTYPE

被引：66

作者：

VOIGT, MM

MCCUNE, SK

KANTERMAN, RY

FELDER, CC

机构：

[1] NICHHD,DEV NEUROBIOL LAB,BETHESDA,MD 20817

[2] HOWARD HUGHES MED INST,NIH RES SCHOLARS PROGRAM,BETHESDA,MD 20892

[3] NINCDS,MOLEC BIOL LAB,BETHESDA,MD 20892

来源：

FEBS LETTERS | 1991年 / 278卷 / 01期

关键词：

ALPHA-2-ADRENOCEPTOR; GENE EXPRESSION; GENE COUPLING; CAMP INHIBITION;

D O I：

10.1016/0014-5793(91)80080-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A rat gene and brain cDNA (pA2d) encoding the homologue of the human alpha-C4 adrenergic receptor subtype were isolated and characterized. RNA blots indicate that this gene is expressed in brain, heart and kidney but not in lung, liver or pancreas. Yohimbine, WB-4101 and prasozin all exhibited high affinity for this receptor in binding studies. Clonidine was more potent and efficacious than norepinephrine in inhibiting forskolin-stimulated cAMP production in CHO cells expressing pA2d. Together, these data suggest that the alpha-2-C4 gene product defines a previously undescribed pharmacological subtype of alpha-2-adrenergic receptor.

引用

页码：45 / 50

页数：6

共 19 条

[1] ALPHA-2-ADRENOCEPTOR-MEDIATED HYPERPOLARIZATION OF LOCUS COERULEUS NEURONS - INTRACELLULAR STUDIES INVIVO [J].