5-HT1B RECEPTORS IN AN ANIMAL-MODEL OF DEPRESSION

被引：52

作者：

EDWARDS, E

HARKINS, K

WRIGHT, G

HENN, FA

机构：

[1] Department of Psychiatry, Behavioral Science State University of New York at Stony Brook, Stony Brook

来源：

NEUROPHARMACOLOGY | 1991年 / 30卷 / 01期

基金：

美国国家科学基金会;

关键词：

LEARNED HELPLESSNESS; STRESS; 5-HYDROXYTRYPTAMINE (5-HT); SEROTONIN RECEPTOR; 5-HT1A BINDING SITES; 5-HT1B BINDING SITES; DEPRESSION;

D O I：

10.1016/0028-3908(91)90050-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

After exposure to a 0.8 mA course of uncontrollable shocks, Sprague-Dawley rats can be differentiated into two distinct groups defined in term of their performance in a shock escape paradigm. Learned helpless (LH) rats do not learn to escape a controllable shock while non-helpless (NLH) rats learn this response as quickly as naive controls (NC) rats do. The current experiments were designed to extend our studies of 5-HT receptors in these three groups of rats. The major finding in the present study concerned post-synaptic 5-HT receptor effects in the cortex, hippocampus, septum and hypothalamus of LH rats. These included an up regulation of 5-HT(lb) receptors in the cortex, hippocampus and septum in LH rats. In contrast, 5-HT(lb) receptors in the hypothalamus of LH rats were down-regulated. These results implicate serotonergic mechanisms in the behavioral deficit caused by uncontrollable shock with a limbichypothalamic circuit serving as a center for adaptation to stress.

引用

页码：101 / 105

页数：5

共 13 条

[1]

APRISON MH, 1978, NEUROPHARMACOLOGY BE, P23

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