A MULTIATTRIBUTE-UTILITY-FUNCTION APPROACH TO WEIGHING THE RISKS AND BENEFITS OF PHARMACEUTICAL AGENTS

被引：13

作者：

ERIKSEN, S ^{[1
]}

KELLER, LR ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,GRAD SCH MANAGEMENT,IRVINE,CA 92717

来源：

MEDICAL DECISION MAKING | 1993年 / 13卷 / 02期

关键词：

DECISION ANALYSIS; EXPECTED UTILITY; DOSAGE SELECTION; COMPOUND COMPARISON; PHARMACEUTICAL DECISION; MULTIATTRIBUTE UTILITY; RISK BENEFIT RATIO;

D O I：

10.1177/0272989X9301300205

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Both the selection of doses of pharmaceutical agents and comparisons between pharmaceutical agents have long been based on the nonquantified concept of the risk-benefit ratio. Though useful, this concept implies a data comparison that is difficult to make: the toxicity versus the efficacy of a drug compound. This research demonstrates an approach f or weighing risks and benefits by combining utility functions for human efficacy and toxicity with animal and laboratory toxicity information to develop an overall multiattribute utility function for an ophthalmic pharmaceutical agent, I-bunolol, intended for the treatment of glaucoma. With this multiattribute function and a small portion of the published data available for this drug, the expected utilities for six doses (including a control) could be compared and the value of this approach in drug-dosage selection demonstrated.

引用

页码：118 / 125

页数：8

共 17 条

[1]

ERIKSEN S, THESIS ANN ARBOR

[2]

Fishburn P.C., 1967, MANAGE SCI, V13, P435, DOI DOI 10.1287/MNSC.13.7.435

[3]

JACOBY I, 1986, ISRAEL J MED SCI, V22, P183

[4] DECISION-ANALYSIS - A PROGRESS REPORT [J].