SEPARATION OF CODEINE AND ITS BY-PRODUCTS BY CAPILLARY ZONE ELECTROPHORESIS AS A QUALITY-CONTROL TOOL IN THE PHARMACEUTICAL-INDUSTRY

被引：24

作者：

KORMAN, M ^{[1
]}

VINDEVOGEL, J ^{[1
]}

SANDRA, P ^{[1
]}

机构：

[1] STATE UNIV GHENT,DEPT ORGAN CHEM,KRIJGSLAAN 281 S4,B-9000 GHENT,BELGIUM

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 645卷 / 02期

关键词：

D O I：

10.1016/0021-9673(93)83397-B

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Capillary zone electrophoresis can be used for the detection of by-products in purified codeine. Separation of the by-products thebaine and 6-methylcodeine illustrates that small geometrical differences can be exploited to achieve effective separation. Examples of the capillary zone electrophoresis and micellar electrokinetic chromatography of codeine-containing drug formulations are presented.

引用

页码：366 / 370

页数：5

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