IMAGING SEQUENCE SPACE

被引：25

作者：

YOUVAN, DC

机构：

[1] Palo Alto Inst. for Molec. Medicine, Mountain View, CA 94043

来源：

NATURE | 1994年 / 369卷 / 6475期

关键词：

D O I：

10.1038/369079a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Digital imaging spectrophotometers can simultaneously measure the spectra of hundreds of features in a two-dimensional scene. While a variety of applications can be anticipated, a colorimetric analysis of mutants expressing pigmented proteins has already led to the development of efficient algorithms for optimizing combinatorial mutagenesis.

引用

收藏

页码：79 / 80

页数：2

相关论文

共 9 条

[1] APPLICATIONS OF IMAGING SPECTROSCOPY IN MOLECULAR-BIOLOGY .2. COLONY SCREENING BASED ON ABSORPTION-SPECTRA [J].

ARKIN, AP ;

GOLDMAN, ER ;

ROBLES, SJ ;

GODDARD, CA ;

COLEMAN, WJ ;

YANG, MM ;

YOUVAN, DC .

BIO-TECHNOLOGY, 1990, 8 (08) :746-749

[2] OPTIMIZING NUCLEOTIDE MIXTURES TO ENCODE SPECIFIC SUBSETS OF AMINO-ACIDS FOR SEMI-RANDOM MUTAGENESIS [J].

ARKIN, AP ;

YOUVAN, DC .

BIO-TECHNOLOGY, 1992, 10 (03) :297-300

[3] SEMISYNTHETIC COMBINATORIAL ANTIBODY LIBRARIES - A CHEMICAL SOLUTION TO THE DIVERSITY PROBLEM [J].

BARBAS, CF ;

BAIN, JD ;

HOEKSTRA, DM ;

LERNER, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4457-4461

[4] SEARCHING SEQUENCE SPACE TO ENGINEER PROTEINS - EXPONENTIAL ENSEMBLE MUTAGENESIS [J].

DELAGRAVE, S ;

YOUVAN, DC .

BIO-TECHNOLOGY, 1993, 11 (13) :1548-1552

[5] RECURSIVE ENSEMBLE MUTAGENESIS [J].

DELAGRAVE, S ;

GOLDMAN, ER ;

YOUVAN, DC .

PROTEIN ENGINEERING, 1993, 6 (03) :327-331

[6] AN ALGORITHMICALLY OPTIMIZED COMBINATORIAL LIBRARY SCREENED BY DIGITAL IMAGING SPECTROSCOPY [J].

GOLDMAN, ER ;

YOUVAN, DC .

BIO-TECHNOLOGY, 1992, 10 (12) :1557-1561

[7] APPLICATIONS OF IMAGING SPECTROSCOPY IN MOLECULAR-BIOLOGY .1. SCREENING PHOTOSYNTHETIC BACTERIA [J].

YANG, MM ;

YOUVAN, DC .

BIO-TECHNOLOGY, 1988, 6 (08) :939-942

[8]

YANG MM, IN PRESS AM BIOTECH

[9]

YOUVAN DC, IN PRESS METH ENZYM