SYNTHESIS OF CONFORMATIONALLY RESTRICTED RELATIVES OF THE MEVINIC ACIDS

被引：6

作者：

BENNETT, F

FENTON, G

KNIGHT, DW

机构：

[1] CHEM DEPT,NOTTINGHAM NG7 2RD,ENGLAND

[2] RHONE POULENC RORER,CENT RES,DAGENHAM RM10 7XS,ESSEX,ENGLAND

来源：

TETRAHEDRON | 1994年 / 50卷 / 17期

关键词：

D O I：

10.1016/S0040-4020(01)90425-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Condensations between the tricyclic ketones 9, 19 and 23 and the sodio-lithio dianion of methyl acetoacetate Lead to the conformationally restricted Mevinic acid relatives 12b, 20b and 26 respectively, following lactonization and selective reduction. The approach of the nucleophile is stereospecific in the first two instances but not in the last; explanations for this behaviour are given. The target compounds showed negligible HMGCoA reductase antagonism.

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页码：5147 / 5158

页数：12

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