MORPHOLOGICAL CHARACTERIZATION OF BIOERODIBLE POLYMERS .1. CRYSTALLINITY OF POLYANHYDRIDE COPOLYMERS

被引：75

作者：

MATHIOWITZ, E ^{[1
]}

RON, E ^{[1
]}

MATHIOWITZ, G ^{[1
]}

AMATO, C ^{[1
]}

LANGER, R ^{[1
]}

机构：

[1] MIT,DEPT CHEM ENGN,CAMBRIDGE,MA 02139

来源：

MACROMOLECULES | 1990年 / 23卷 / 13期

关键词：

D O I：

10.1021/ma00215a003

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The composition of polyanhydrides has been a critical determinant in enabling different erosion rates of these polymers. Since crystallinity is an important factor in controlling polymer erosion rates, an in-depth analysis of the effect of polymer composition on crystallinity was undertaken using a variety of polyanhydrides. Polyanhydride homopolymers and copolymers made of sebacic acid (SA), (carboxyphenoxy)propane (CPP), (carboxyphenoxy)hexane (CPH), and fumaric acid (FA) were studied. Crystallinity was analyzed by the following: (1) X-ray diffraction, (2) a combination of X-ray diffraction and differential scanning calorimetry (DSC), and (3) data generated from1H NMR spectroscopy and Flory’s equilibrium theory. Homopolymers such as poly(sebacic anhydride), poly(fumaric anhydride), and poly(l,3-bis(p-carboxyphenoxy)propane anhydride) were crystalline, and each displayed a typical powder diffraction. In copolymers, diffraction patterns were determined, in most cases, by the monomer of highest concentration. Copolymers with high ratios of SA or CPP had a high crystallinity while copolymers with almost equal ratios of SA and CPP or SA and CPH were amorphous. The poly(SA-FA) series displayed high crystallinity regardless of monomer concentration. © 1990, American Chemical Society. All rights reserved.

引用

页码：3212 / 3218

页数：7

共 17 条

[1] AROMATIC POLYANHYDRIDES, A NEW CLASS OF HIGH MELTING FIBER-FORMING POLYMERS [J].