STRAND SCISSION IN DNA INDUCED BY L-DOPA IN THE PRESENCE OF CU(II)

被引：45

作者：

HUSAIN, S ^{[1
]}

HADI, SM ^{[1
]}

机构：

[1] ALIGARH MUSLIM UNIV,FAC LIFE SCI,DEPT BIOCHEM,ALIGARH 202002,UTTAR PRADESH,INDIA

来源：

FEBS LETTERS | 1995年 / 364卷 / 01期

关键词：

DNA CLEAVAGE; L-DOPA; COPPER; REACTIVE OXYGEN SPECIES;

D O I：

10.1016/0014-5793(95)00365-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been recently reported that L-DOPA and CuO(II) in the presence of H2O2 leads to extensive DNA damage. In this paper we show that L-DOPA in the presence of CuO alone can cause DNA cleavage through the generation of reactive oxygen species such as the hydroxyl radical. Fluorescence quenching studies indicate that L-DOPA is capable of binding to DNA.

引用

页码：75 / 78

页数：4

共 30 条

[1]

AHMED MS, 1994, MUTAGENESIS, V3, P193

[2] DIETARY CARCINOGENS AND ANTICARCINOGENS - OXYGEN RADICALS AND DEGENERATIVE DISEASES [J].

AMES, BN .

SCIENCE, 1983, 221 (4617) :1256-1264

[3] COPPER-ION-DEPENDENT DAMAGE TO THE BASES IN DNA IN THE PRESENCE OF HYDROGEN-PEROXIDE [J].

ARUOMA, OI ;

HALLIWELL, B ;

GAJEWSKI, E ;

DIZDAROGLU, M .

BIOCHEMICAL JOURNAL, 1991, 273 :601-604

[4] COPPER-DEPENDENT CLEAVAGE OF DNA BY BLEOMYCIN [J].

EHRENFELD, GM ;

SHIPLEY, JB ;

HEIMBROOK, DC ;

SUGIYAMA, H ;

LONG, EC ;

VANBOOM, JH ;

VANDERMAREL, GA ;

OPPENHEIMER, NJ ;

HECHT, SM .

BIOCHEMISTRY, 1987, 26 (03) :931-942

[5] OXIDATIVE DESTRUCTION OF DNA BY THE ADRIAMYCIN IRON COMPLEX [J].

ELIOT, H ;

GIANNI, L ;

MYERS, C .

BIOCHEMISTRY, 1984, 23 (05) :928-936

[6] CONTINUOUS MONITORING OF INVITRO OXIDATION OF HUMAN LOW-DENSITY LIPOPROTEIN [J].

ESTERBAUER, H ;

STRIEGL, G ;

PUHL, H ;

ROTHENEDER, M .

FREE RADICAL RESEARCH COMMUNICATIONS, 1989, 6 (01) :67-75

[7] STRAND SCISSION IN DNA BY QUERCETIN AND CU(II) - IDENTIFICATION OF FREE-RADICAL INTERMEDIATES AND BIOLOGICAL CONSEQUENCES OF SCISSION [J].

FAZAL, F ;

RAHMAN, A ;

GREENSILL, J ;

AINLEY, K ;

HADI, SM ;

PARISH, JH .

CARCINOGENESIS, 1990, 11 (11) :2005-2008

[8] MECHANISMS OF MUTATION BY OXIDATIVE DNA DAMAGE - REDUCED FIDELITY OF MAMMALIAN DNA POLYMERASE-BETA [J].

FEIG, DI ;

LOEB, LA .

BIOCHEMISTRY, 1993, 32 (16) :4466-4473

[9] PROTEIN-BOUND 3,4-DIHYDROXYPHENYLALANINE IS A MAJOR REDUCTANT FORMED DURING HYDROXYL RADICAL DAMAGE TO PROTEINS [J].

GIESEG, SP ;

SIMPSON, JA ;

CHARLTON, TS ;

DUNCAN, MW ;

DEAN, RT .

BIOCHEMISTRY, 1993, 32 (18) :4780-4786

[10]

HALLIWELL B, 1990, METHOD ENZYMOL, V186, P1

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