FOCAL ADHESION KINASE IS NOT ESSENTIAL FOR IN-VITRO AND IN-VIVO DIFFERENTIATION OF ES CELLS

被引：55

作者：

ILIC, D

FURUTA, Y

SUDA, T

ATSUMI, T

FUJIMOTO, J

IKAWA, Y

YAMAMOTO, T

AIZAWA, S

机构：

[1] INST PHYS & CHEM RES,TSUKUBA LIFE SCI CTR,MOLEC ONCOL LAB,TSUKUBA,IBARAKI 305,JAPAN

[2] UNIV TOKYO,INST MED SCI,DEPT ONCOL,MINATO KU,TOKYO 108,JAPAN

[3] KUMAMOTO UNIV,SCH MED,INST EMBRYOL & GENET,DEPT MORPHOGENESIS,KUMAMOTO 860,JAPAN

[4] KUMAMOTO UNIV,SCH MED,INST EMBRYOL & GENET,DEPT CELL DIFFERENTIAT,KUMAMOTO 860,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 209卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.1503

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Focal adhesion kinase, FAK, is a unique protein tyrosine kinase found in cellular focal adhesions. It is widely expressed and highly phosphorylated during embryogenesis. To examine the function of FAK in cell differentiation, we made FAK-deficient embryonic stem (ES) cells by homologous recombination. However, FAK deficiency did not interfere with differentiation of the ES cells into cells of three germ layers when implanted subcutaneously into nude mice or when treated with retinoic acid in vitro, nor was there any evidence of defects in hematopoiesis in vitro. (C) 1995 Academic Press, Inc.

引用

页码：300 / 309

页数：10

共 28 条

[1] LOCALIZATION AND SYNTHESIS OF SOME COLLAGEN TYPES IN DEVELOPING MOUSE EMBRYOS [J].