AN IMPROVED DNA-BASED IDENTIFICATION OF FETUSES AT RISK FOR HPA-1A (PL(AL)) NEONATAL ALLOIMMUNE THROMBOCYTOPENIA

被引：12

作者：

CLEMENCEAU, S

PERICHON, B

ELION, J

KAPLAN, C

KRISHNAMOORTHY, R

机构：

[1] HOP ROBERT DEBRE,INSERM,U120,F-75935 PARIS 19,FRANCE

[2] INST NATL TRANSFUS SANGUINE,PARIS,FRANCE

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1994年 / 86卷 / 01期

关键词：

THROMBOCYTOPENIA; FETUS; DNA AMPLIFICATION; HPAII MAPPING;

D O I：

10.1111/j.1365-2141.1994.tb03277.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A simple and reliable procedure, based on DNA amplification and HpaII mapping, is proposed for the identification of fetuses at risk for HPA-la (Pl(a1)) neonatal alloimmune thrombocytopenia which could cause life-threatening haemorrhage, even in early fetal life. This typing procedure for HPA-1 alleles should help in deciding, very early, the therapeutic management of the fetuses at risk.

引用

页码：198 / 200

页数：3

共 7 条

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[4] KAPLAN C, 1988, BLOOD, V72, P340
[5] TYPING OF FETAL PLATELET ALLOANTIGENS WHEN PLATELETS ARE NOT AVAILABLE
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[J]. LANCET, 1990, 336 (8726) : 1319 - 1319
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[7] THE HUMAN-PLATELET ALLOANTIGENS, PIA1 AND PIA2, ARE ASSOCIATED WITH A LEUCINE-33 PROLINE-33 AMINO-ACID POLYMORPHISM IN MEMBRANE GLYCOPROTEIN IIIA, AND ARE DISTINGUISHABLE BY DNA TYPING
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