A NEW NEURONAL CELL PROTECTING SUBSTANCE, LAVANDUQUINOCIN, PRODUCED BY STREPTOMYCES VIRIDOCHROMOGENES

被引：65

作者：

SHINYA, K ^{[1
]}

SHIMIZU, S ^{[1
]}

KUNIGAMI, T ^{[1
]}

FURIHATA, K ^{[1
]}

SETO, H ^{[1
]}

机构：

[1] UNIV TOKYO,DIV AGR & AGR LIFE SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 07期

关键词：

D O I：

10.7164/antibiotics.48.574

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new neuronal cell protecting substance, lavanduquinocin was isolated from Streptomyces viridochromogenes 2942-SVS3. It consists of a carbazole skeleton with an ortho quinone function and a cyclolavandulyl moiety. Lavanduquinocin protected neuronal hybridoma N18-RE-105 cells from L-glutamate toxicity with EC(50) value 15.5 nM.

引用

页码：574 / 578

页数：5

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