RHODOPSIN ACTIVATION CAUSES RETINAL DEGENERATION IN DROSOPHILA RDGC MUTANT

被引：73

作者：

STEELE, F

OTOUSA, JE

机构：

[1] Department of Biological Sciences University of Notre Dame Notre Dame, Indiana USA

来源：

NEURON | 1990年 / 4卷 / 06期

关键词：

D O I：

10.1016/0896-6273(90)90141-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Drosophila rdgC (retinal degeneration-C) mutants show normal retinal morphology and photoreceptor physiology at young ages. Dark-reared rdgC flies retain this wild-type phenotype, but light-reared mutants undergo retinal degeneration. rdgC photoreceptors with low levels of rhodopsin as a result of vitamin A deprivation or a mutant rhodopsin (ninaE) gene fail to show rdgC induced degeneration even after prolonged light treatment, demonstrating that degeneration occurs as a result of light stimulation of rhodopsin. Analysis of norpA; rdgC flies shows that the norpA-encoded phospholipase C, the target enzyme of the G protein activated by rhodopsin, is not required for rdgC-induced degeneration. Thus the rdgC+ gene product is required to prevent retinal degeneration that results from a previously unrecognized consequence of rhodopsin stimulation. © 1990.

引用

页码：883 / 890

页数：8

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