CONTROLLABILITY AND DURATION OF STRESS ALTER CENTRAL-NERVOUS-SYSTEM DEPRESSANT INDUCED SLEEP TIME IN RATS

被引：13

作者：

DRUGAN, RC ^{[1
]}

SCHER, DM ^{[1
]}

SARABANCHONG, V ^{[1
]}

GUGLIELMI, AM ^{[1
]}

MENG, I ^{[1
]}

CHANG, J ^{[1
]}

BLOOM, K ^{[1
]}

SYLVIA, S ^{[1
]}

HOLMES, P ^{[1
]}

机构：

[1] BROWN UNIV,SCHRIER RES LAB,PROVIDENCE,RI 02912

来源：

BEHAVIORAL NEUROSCIENCE | 1992年 / 106卷 / 04期

关键词：

D O I：

10.1037/0735-7044.106.4.682

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Rats were exposed to either 80 escapable shocks or yoked inescapable shocks and then injected with several hypnotic doses of sodium pentobarbital, midazolam, or ethanol; their sleep-time duration was compared with that of naive controls. Inescapable shock exposure resulted in a significant increase in ethanol-induced sleep time compared with the escapable shock and naive control groups. Both escape and yoked groups showed an increase in barbiturate-induced sleep time compared with controls, although no difference was observed for midazolam. Acute stress (twenty 5-s inescapable shocks) did not alter the depressant-induced sleep time for any of the drugs tested. These results illustrate the importance of psychological aspects of stress and its influence on the potency of certain depressants.

引用

页码：682 / 689

页数：8

共 51 条

[1] RAPID CHANGES IN GABA BINDING INDUCED BY STRESS IN DIFFERENT AREAS OF THE RAT-BRAIN [J].