A NOVEL MEMBER OF THE INTERFERON RECEPTOR FAMILY COMPLEMENTS FUNCTIONALITY OF THE MURINE INTERFERON-GAMMA RECEPTOR IN HUMAN-CELLS

被引：186

作者：

HEMMI, S

BOHNI, R

STARK, G

DIMARCO, F

AGUET, M

机构：

[1] Institute of Molecular Biology I University of Zürich Hönggerberg

来源：

CELL | 1994年 / 76卷 / 05期

关键词：

D O I：

10.1016/0092-8674(94)90355-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of the human interferon gamma receptor (IFN-gamma R) in mouse cells is not sufficient to confer biological responsiveness to human IFN-gamma and vice versa. An additional species-specific component is required for signal transduction. We identified this cofactor by expression cloning in simian COS cells stably transfected with the nonfunctional murine IFN-gamma R and a IFN-gamma-inducible reporter construct encoding the human Tac antigen (interleukin-2 receptor alpha chain, CD25). A cDNA clone was obtained that, upon stable transfection, rendered human HEp-2 cells expressing the murine IFN-gamma R fully responsive to murine IFN-gamma. This cDNA encodes a novel 332 amino acid type I transmembrane protein that belongs to the IFN receptor family and that we designate IFN-gamma R beta chain.

引用

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页码：803 / 810

页数：8

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