WHAT IS AN IDIOTYPE

被引：26

作者：

JEFFERIS, R

机构：

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 03期

关键词：

D O I：

10.1016/0167-5699(93)90211-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Idiotypy is an important concept with significant practical implications for the manipulation of B- and T-cell clones. However, this potential depends on a correct identification of idiotypy and the development of appropriate reagents. Current knowledge of the structure and polymorphism within the Ig loci reveals that several idiotypic paradigms are based on isotypic or allotypic structures rather than supposed crossreactive idiotypes.

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页码：119 / 121

页数：3

相关论文

共 19 条

[1] NEW ROLES FOR RHEUMATOID-FACTOR [J].

CARSON, DA ;

CHEN, PP ;

KIPPS, TJ .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (02) :379-383

[2] IDIOTYPIC AND GENETIC-STUDIES OF HUMAN RHEUMATOID FACTORS [J].

CARSON, DA ;

CHEN, PP ;

KIPPS, TJ ;

RADOUX, V ;

JIRIK, FR ;

GOLDFIEN, RD ;

FOX, RI ;

SILVERMAN, GJ ;

FONG, S .

ARTHRITIS AND RHEUMATISM, 1987, 30 (12) :1321-1325

[3]

JEFFERIS R, 1989, MONOGR ALLERGY, V26, P45

[4]

KABAT EA, 1987, SEQUENCES IMMUNOLOGI

[5] POLYMORPHISM IN VK10 GENES ENCODING L-CHAINS OF ANTIBODIES BEARING THE ARS-A AND A48 CROSS-REACTIVE IDIOTYPES [J].

KIM, SO ;

SANZ, I ;

WILLIAMS, C ;

CAPRA, JD ;

GOTTLIEB, PD .

IMMUNOGENETICS, 1991, 34 (04) :231-241

[6]

Kindt T.J., 1984, ANTIBODY ENIGMA

[7] RESTRICTED VH GENE USAGE AND GENERATION OF ANTIBODY DIVERSITY IN RABBIT [J].

KNIGHT, KL .

ANNUAL REVIEW OF IMMUNOLOGY, 1992, 10 :593-616

[8] INDIVIDUAL ANTIGENIC SPECIFICITY OF ISOLATED ANTIBODIES [J].

KUNKEL, HG ;

MANNIK, M ;

WILLIAMS, RC .

SCIENCE, 1963, 140 (357) :1218-&

[9]

LUI MF, 1989, J IMMUNOL, V142, P688

[10] SELECTIVE EXPRESSION OF A VHIV SUBFAMILY OF IMMUNOGLOBULIN GENES IN HUMAN CD5+ LYMPHOCYTES-B FROM CORD BLOOD [J].

MAGEED, RA ;

MACKENZIE, LE ;

STEVENSON, FK ;

YUKSEL, B ;

SHOKRI, F ;

MAZIAK, BR ;

JEFFERIS, R ;

LYDYARD, PM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (01) :109-113