TUMOR-NECROSIS-FACTOR-ALPHA IN SERUM OF MACAQUES DURING SIVMAC251 ACUTE INFECTION

被引：10

作者：

CLAYETTE, P

LEGRAND, R

NOACK, O

VASLIN, B

LENAOUR, R

BENVENISTE, O

THEODORO, F

FRETIER, P

DORMONT, D

机构：

[1] Laboratoire de Neuropathologie expérimentale et Neurovirologie, CEA, DSV, DPTE, SSA, Institut Paris-Sud sur les Cytokines, Fontenay Aux Roses

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 1995年 / 24卷 / 02期

关键词：

CYTOKINE; INFLAMMATION; ANIMAL MODEL; SIMIAN IMMUNODEFICIENCY VIRUS;

D O I：

10.1111/j.1600-0684.1995.tb00152.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

TNF secretion was explored in sera during acute SIV-infection of cynomolgus macaques. A peak of TNF was detected in sera of animals in concomitance with SIV replication. Likewise, AZT treatment delayed acid reduced peaks of viral replication and TNF production. Thus, SIVmac251-infected monkey could be an excellent model to explore the interdigitation existing between HIV and TNF in acute and chronic infection and to develop new therapeutic strategies that target the production of this cytokine or its inductive effects.

引用

页码：94 / 100

页数：7

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