SERUM BETA-N-ACETYLGLUCOSAMINIDASE IN PATIENTS WITH SYMPTOMATIC PORPHYRIA

被引：7

作者：

APOSTOLOV, I ^{[1
]}

IVANOV, E ^{[1
]}

ADJAROV, D ^{[1
]}

机构：

[1] MED ACAD SOFIA, CTR HYG, INST NUTR, SOFIA 1431, BULGARIA

来源：

ENZYME | 1976年 / 21卷 / 04期

关键词：

D O I：

10.1159/000458871

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies in 30 male patients with symptomatic porphyria reveal an increased activity in the serum of the lysosomal enzyme .beta.-N-acetylglucosaminidase (EC 3.2.1.30) as compared with a control group of 33 healthy males. Enzymatic activity is higher in the active stage of the disease (with fresh skin lesions) than in patients found in remission. A high degree of correlation was detected between the activity of .beta.-N-acetylglucosaminidase in the serum and uroporphyrin in the urine, and the total plasma porphyrins. The increased activity of this enzyme in the serum indicates that the lysosomes participate in the pathogenesis of this disorder.

引用

页码：289 / 295

页数：7

共 26 条

[1]

ADJAROV D, 1973, ACTA HEPATO-GASTRO, V20, P315

[2] ROLE OF LYSOSOMES AND OF CELL MEMBRANES IN PHOTOSENSITIZATION [J].

ALLISON, AC ;

MAGNUS, IA ;

YOUNG, MR .

NATURE, 1966, 209 (5026) :874-&

[3] UPTAKE OF DYES AND DRUGS BY LIVING CELLS IN CULTURE [J].

ALLISON, AC ;

YOUNG, MR .

LIFE SCIENCES, 1964, 3 (12) :1407-1414

[4]

ARBORGH BAM, 1974, LAB INVEST, V30, P664

[5]

ARSTILA AU, 1970, AM J PATHOL, V58, P419

[6]

CREUTZFELDT W, 1966, ACTA HEPATO-SPLENOL, V13, P65

[7] HUMAN SERUM BETA-GLUCURONIDASE - ITS MEASUREMENT AND SOME OF ITS PROPERTIES [J].

FISHMAN, WH ;

KATO, K ;

ANSTISS, CL ;

GREEN, S .

CLINICA CHIMICA ACTA, 1967, 15 (03) :435-&

[8] PLASMA ARYLSULFATASE AND BETA-GLUCURONIDASE IN ACUTE ALCOHOLISM [J].

GEOKAS, MC ;

RINDERKNECHT, H .

CLINICA CHIMICA ACTA, 1973, 46 (01) :27-32

[9] BIOCHEMICAL CHANGES IN THE TISSUES OF ANIMALS INJECTED WITH IRON - ACID PHOSPHATASE AND OTHER ENZYMES [J].

GOLBERG, L ;

MARTIN, LE ;

BATCHELOR, A .

BIOCHEMICAL JOURNAL, 1960, 77 :252-262

[10]

GUTNIAK O, 1958, MED PR, V9, P1

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